Through games of Oct. 30, 2021:
| Rank | School (No. 1 votes) | W-L | Points | Prev. |
| 1 | North Central (Ill.) (18) | 8-0 | 615 | 1 |
| 2 | Mary Hardin-Baylor (7) | 8-0 | 595 | 2 |
| 3 | UW-Whitewater | 8-0 | 580 | 3 |
| 4 | Mount Union | 8-0 | 551 | 4 |
| 5 | St. John's | 8-0 | 506 | 5 |
| 6 | Wheaton (Ill.) | 7-1 | 501 | 6 |
| 7 | Linfield | 7-0 | 471 | 7 |
| 8 | Hardin-Simmons | 7-1 | 426 | 8 |
| 9 | Central | 8-0 | 407 | 9 |
| 10 | Delaware Valley | 8-0 | 401 | 10 |
| 11 | Salisbury | 6-1 | 349 | 11 |
| 12 | UW-La Crosse | 7-1 | 337 | 13 |
| 13 | Union | 8-0 | 331 | 12 |
| 14 | Bethel | 7-1 | 310 | 14 |
| 15 | Cortland | 8-0 | 284 | 16 |
| 16 | Muhlenberg | 7-1 | 242 | 17 |
| 17 | Johns Hopkins | 7-1 | 190 | 20 |
| 18 | Trinity (Texas) | 7-0 | 178 | 19 |
| 19 | Birmingham-Southern | 8-0 | 146 | 22 |
| 20 | UW-Oshkosh | 5-2 | 137 | 21 |
| 21 | Baldwin Wallace | 7-1 | 108 | 23 |
| 22 | Washington and Jefferson | 7-1 | 99 | 24 |
| 23 | RPI | 7-1 | 71 | -- |
| 24 | Ithaca | 7-1 | 68 | 15 |
| 25 | Susquehanna | 7-1 | 54 | 18 |
Dropped out: No. 25 John Carroll.
Others receiving votes: Whitworth 43; John Carroll 41; Randolph-Macon 26; Redlands 16; UW-River Falls 10; DePauw 8; Aurora 7; Claremont-Mudd-Scripps 6; Westminster (Pa.) 6; Albion 2; Chapman 1; Lake Forest 1.
The D3football.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.