Through games of Sept. 11, 2021:
| Rank | School (No. 1 votes) | W-L | Points | Prev. |
| 1 | Mary Hardin-Baylor (13) | 2-0 | 597 | 1 |
| 2 | UW-Whitewater | 2-0 | 577 | 3 |
| 3 | Mount Union (4) | 1-0 | 574 | 2 |
| 4 | North Central (Ill.) (4) | 1-0 | 573 | 4 |
| 5 | Wheaton (Ill.) (4) | 1-0 | 539 | 5 |
| 6 | Hardin-Simmons | 2-0 | 449 | 7 |
| 7 | St. John's | 1-0 | 448 | 6 |
| 8 | Muhlenberg | 2-0 | 419 | 9 |
| 9 | UW-Oshkosh | 2-0 | 396 | 11 |
| 10 | Delaware Valley | 2-0 | 390 | 10 |
| 11 | Linfield | 1-0 | 354 | 12 |
| 12 | Washington and Jefferson | 2-0 | 309 | 13 |
| 13 | Union | 2-0 | 292 | 14 |
| 14 | Salisbury | 1-1 | 288 | 8 |
| 15 | Bethel | 2-0 | 255 | 17 |
| 16 | Central | 2-0 | 249 | 16 |
| 17 | Chapman | 2-0 | 211 | 18 |
| 18 | Randolph-Macon | 2-0 | 205 | 19 |
| 19 | Ithaca | 2-0 | 107 | -- |
| 20 | John Carroll | 0-1 | 106 | 22 |
| 21 | Johns Hopkins | 2-0 | 105 | 25 |
| 22 | Heidelberg | 1-0 | 92 | 23 |
| 23 | Whitworth | 2-0 | 80 | 24 |
| 24 | UW-La Crosse | 2-0 | 79 | -- |
| 25 | Berry | 2-0 | 74 | -- |
Dropped out: No. 15 Wartburg; No. 20 Brockport; No. 21 Aurora.
Others receiving votes: Case Western Reserve 38; Redlands 35; Bridgewater (Va.) 30; Hobart 30; Cortland 29; Wabash 25; Westminster (Pa.) 25; Aurora 21; Wartburg 21; Gustavus Adolphus 21; Brockport 16; Centre 13; Susquehanna 13; East Texas Baptist 13; Baldwin Wallace 8; Birmingham Southern 7; Western New England 5; Middlebury 4; RPI 2; Trinity (Texas) 1.
The D3football.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.