Through games of Sept. 25, 2021:
| Rank | School (No. 1 votes) | W-L | Points | Prev. |
| 1 | North Central (Ill.) (16) | 3-0 | 610 | 1 |
| 2 | Mary Hardin-Baylor (8) | 4-0 | 588 | 2 |
| 3 | UW-Whitewater | 3-0 | 581 | 3 |
| 4 | Mount Union (1) | 3-0 | 564 | 4 |
| 5 | Wheaton (Ill.) | 2-1 | 500 | 5 |
| 6 | St. John's | 3-0 | 490 | 6 |
| 7 | Hardin-Simmons | 3-1 | 458 | 7 |
| 8 | UW-Oshkosh | 2-0 | 421 | 8 |
| 9 | Linfield | 2-0 | 417 | 9 |
| 10 | Delaware Valley | 3-0 | 398 | 10 |
| 11 | Washington and Jefferson | 4-0 | 350 | 11 |
| 12 | Union | 4-0 | 308 | 12 |
| 13 | Central | 4-0 | 306 | 14 |
| 14 | Salisbury | 2-1 | 294 | 15 |
| 15 | Johns Hopkins | 4-0 | 267 | 18 |
| 16 | Bethel | 2-1 | 243 | 13 |
| 17 | Ithaca | 3-0 | 231 | 19 |
| 18 | Whitworth | 3-0 | 172 | 20 |
| 19 | Cortland | 3-0 | 121 | 25 |
| 20 | UW-La Crosse | 2-1 | 101 | 23 |
| 21 | Hobart | 4-0 | 85 | -- |
| 22 | John Carroll | 1-2 | 81 | 21 |
| 23 | Muhlenberg | 3-1 | 73 | 24 |
| 24 | Westminster (Pa.) | 2-1 | 51 | -- |
| 25 | Susquehanna | 4-0 | 49 | -- |
Dropped out: No. 16 Randolph-Macon; No. 17 Chapman; No. 22 Heidelberg.
Others receiving votes: Baldwin Wallace 44; Gustavus Adolphus 42; Berry 33; Birmingham-Southern 28; Wabash 26; Centre 21; Chapman 21; Albion 19; RPI 18; Randolph-Macon 17; Ursinus 17; Aurora 14; Claremont-Mudd-Scripps 14; UW-Stout 11; Wartburg 10; Trinity (Texas) 10; Howard Payne 10; Carthage 3; UW-River Falls 3; Ohio Wesleyan 2; Salve Regina 2; Widener 1.
The D3football.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.