Through games of Oct. 23, 2021:
| Rank | School (No. 1 votes) | W-L | Points | Prev. |
| 1 | North Central (Ill.) (17) | 7-0 | 613 | 1 |
| 2 | Mary Hardin-Baylor (7) | 7-0 | 595 | 2 |
| 3 | UW-Whitewater | 7-0 | 573 | 3 |
| 4 | Mount Union (1) | 7-0 | 566 | 4 |
| 5 | St. John's | 7-0 | 498 | 5 |
| 6 | Wheaton (Ill.) | 6-1 | 482 | 6 |
| 7 | Linfield | 6-0 | 471 | 7 |
| 8 | Hardin-Simmons | 6-1 | 426 | 8 |
| 9 | Central | 7-0 | 414 | 10 |
| 10 | Delaware Valley | 7-0 | 410 | 9 |
| 11 | Salisbury | 5-1 | 340 | 12 |
| 12 | Union | 7-0 | 324 | 13 |
| 13 | UW-La Crosse | 6-1 | 315 | 14 |
| 14 | Bethel | 6-1 | 299 | 15 |
| 15 | Ithaca | 7-0 | 282 | 16 |
| 16 | Cortland | 7-0 | 262 | 17 |
| 17 | Muhlenberg | 6-1 | 217 | 18 |
| 18 | Susquehanna | 7-0 | 198 | 19 |
| 19 | Trinity (Texas) | 6-0 | 128 | 21 |
| 20 | Johns Hopkins | 6-1 | 117 | 20 |
| 21 | UW-Oshkosh | 4-2 | 110 | 23 |
| 22 | Birmingham-Southern | 7-0 | 109 | 22 |
| 23 | Baldwin Wallace | 6-1 | 88 | 25 |
| 24 | Washington and Jefferson | 6-1 | 70 | 11 |
| 25 | John Carroll | 5-2 | 39 | 24 |
Dropped out: None.
Others receiving votes: Whitworth 37; Hobart 37; Gustavus Adolphus 21; Randolph-Macon 19; Redlands 17; Westminster (Pa.) 12; Merchant Marine 11; Claremont-Mudd-Scripps 6; Aurora 5; UW-River Falls 4; Wilkes 3; RPI 3; DePauw 2; Chapman 1; UW-Stout 1.
The D3football.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.