2010 Schedule DePauw
| Overall | Pct. | Conf. | Pct. | Streak | Home | Away | Neutral |
| 9-2 | .818 | 6-0 | 1.000 | Lost 2 | 6-1 | 3-1 | 0-0 |
| Date | Opponent | Result | Time/Status | Links |
| Sep. 11 | Rose-Hulman | W, 45-16 | Final | BX BX RC |
| Sep. 18 | at Centre * | W, 21-16 | Final | |
| Sep. 25 | Sewanee * | W, 35-7 | Final | RC |
| Oct. 2 | at Millsaps * | W, 35-21 | Final | |
| Oct. 9 | Rhodes * | W, 42-18 | Final | BX RC |
| Oct. 16 | Adrian | W, 23-19 | Final | BX RC RC P |
| Oct. 23 | at Trinity (Texas) * | W, 32-31 | Final | BX RC |
| Oct. 30 | Birmingham-Southern | W, 30-23 | Final | BX RC |
| Nov. 6 | Austin * | W, 30-20 | Final | RC |
| Nov. 13 | at Wabash | L, 47-0 | Final | BX RC |
| Nov. 20 | Trine | L, 45-35 | Final | BX RC RC |
| NCAA Playoffs - 1st Round | ||||
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