2010 Schedule Lewis and Clark
| Overall | Pct. | Conf. | Pct. | Streak | Home | Away | Neutral |
| 4-5 | .444 | 2-4 | .333 | Lost 3 | 3-2 | 1-3 | 0-0 |
| Date | Opponent | Result | Time/Status | Links |
| Sep. 11 | at Claremont-Mudd-Scripps | L, 65-21 | Final | BX BX RC |
| Sep. 18 | Pomona-Pitzer | W, 63-38 | Final | BX |
| Sep. 25 | at Whitworth * | L, 38-20 | Final | BX |
| Oct. 2 | Pacific * | W, 48-0 | Final | BX RC |
| Homecoming | ||||
| Oct. 9 | Menlo | W, 31-10 | Final | BX RC |
| Oct. 23 | at Puget Sound * | W, 68-64 | Final | BX BX RC RC P |
| Oct. 30 | Pacific Lutheran * | L, 35-23 | Final | BX BX RC RC |
| Nov. 6 | at Willamette * | L, 65-24 | Final | BX BX BX RC |
| Nov. 13 | Linfield * | L, 52-0 | Final | BX RC |
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