2010 Schedule Knox
| Overall | Pct. | Conf. | Pct. | Streak | Home | Away | Neutral |
| 1-9 | .100 | 1-8 | .111 | Lost 4 | 1-4 | 0-5 | 0-0 |
| Date | Opponent | Result | Time/Status | Links |
| Sep. 4 | at Washington U. | L, 34-3 | Final | BX BX RC |
| Sep. 11 | at Lawrence * | L, 33-12 | Final | |
| Sep. 18 | St. Norbert * | L, 49-0 | Final | RC |
| Sep. 25 | at Beloit * | L, 42-7 | Final | RC |
| Oct. 2 | Ripon * | L, 56-14 | Final | |
| Oct. 9 | Grinnell * | W, 31-21 | Final | |
| Oct. 16 | at Illinois College * | L, 31-23 | Final | |
| Oct. 23 | Carroll * | L, 35-0 | Final | |
| Oct. 30 | at Lake Forest * | L, 35-6 | Final | BX |
| Nov. 6 | Monmouth * | L, 42-6 | Final | |
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