Through games of Nov. 13, 2021:
| Rank | School (No. 1 votes) | W-L | Points | Prev. |
| 1 | North Central (Ill.) (18) | 10-0 | 616 | 1 |
| 2 | Mary Hardin-Baylor (7) | 10-0 | 597 | 2 |
| 3 | UW-Whitewater | 10-0 | 580 | 3 |
| 4 | Mount Union | 10-0 | 548 | 4 |
| 5 | St. John's | 10-0 | 499 | 5 |
| 6 | Wheaton (Ill.) | 9-1 | 497 | 6 |
| 7 | Linfield | 9-0 | 476 | 7 |
| 8 | Central | 10-0 | 412 | 9 |
| 9 | Delaware Valley | 10-0 | 406 | 10 |
| 10 | Hardin-Simmons | 9-1 | 399 | 8 |
| 11 | UW-La Crosse | 8-2 | 359 | 12 |
| 12 | Salisbury | 8-1 | 347 | 11 |
| 13 | Cortland | 10-0 | 333 | 14 |
| 14 | Bethel | 8-2 | 295 | 13 |
| 15 | Muhlenberg | 9-1 | 278 | 15 |
| 16 | Trinity (Texas) | 9-0 | 265 | 16 |
| 17 | Johns Hopkins | 9-1 | 214 | 17 |
| 18 | RPI | 9-1 | 193 | 21 |
| 19 | Birmingham-Southern | 9-1 | 177 | 22 |
| 20 | Ithaca | 8-2 | 117 | 18 |
| 21 | Randolph-Macon | 9-1 | 93 | 24 |
| 22 | UW-River Falls | 8-2 | 73 | -- |
| 23 | Aurora | 8-2 | 55 | -- |
| 24 | Lake Forest | 10-0 | 50 | -- |
| 25 | Redlands | 8-1 | 45 | -- |
Dropped out: No. 19 UW-Oshkosh; No. 20 Baldwin Wallace; No. 23 Union; No. 25 DePauw.
Others receiving votes: Albion 36; Carnegie Mellon 36; Williams 23; Heidelberg 20; Baldwin Wallace 20; Union 19; UW-Oshkosh 14; John Carroll 10; Hobart 4; Rose-Hulman 4; Susquehanna 4; Washington & Jefferson 4; DePauw 2; Huntingdon 2; Westminster (Pa.) 2; Merchant Marine 1.
The D3football.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.